Stem Cell Research at Duke Med

March 8, 2018

The following is from Phil Rego & Lauren Tappen.

Early findings by Duke University ophthalmology researcher Dennis Rickman and others indicate that stem cells indeed restore damaged retinas.

“The cells migrate to the area of injury, and in many cases appear to integrate into the tissue and differentiate into those cells,” Rickman said.

But it will take a lot more research before those findings can yield therapy.

https://dukeeyecenter.duke.edu/news-events/researcher-uses-stem-cells-eye-disease

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Osteoporosis Treatment and Macular Degeneration

March 4, 2018

Bisphosphonates, which are typically used to prevent osteoporosis, are some of the most prescribed drugs. They are known to increase the risk of inflammatory eye diseases such as scleritis, uveitis, and optic neuritis, and their pro-inflammatory properties may account for this increased risk as well as the flu-like symptoms that have been reported as adverse effects of their use.

The appearance of flu-like symptoms after use of the injected bisphosphonate zolendronic acid (Reclast/Novartis) has been attributed to the release of inflammatory mediators such as C-reactive protein. This common marker of systemic inflammation has been associated with coronary artery disease and implicated in the development of age-related macular degeneration (AMD), including its neovascular (wet) form.

For more info:

http://www.mdmag.com/medical-news/oral-bisphosphonate-use-poses-risk-of-wet-age-related-macular-degeneration

https://www.ncbi.nlm.nih.gov/pubmed/27163238

https://www.medscape.com/viewarticle/868998