HIV drug may also treat macular degeneration

Reporting their findings in the journal Science, the international team, led by researchers at the University of Kentucky in Lexington, say because of a previously undiscovered property, the drugs may also be effective against other inflammatory disorders.

In their new study on mice with a condition similar to dry AMD, Prof. Ambati and colleagues show that several FDA-approved NRTIs stopped retinal degeneration. But they were surprised to find it was a previously unknown property of the drugs that produced the results.

They found the NRTIs blocked a type of inflammasome called NLRP3. Inflammasomes are large complexes of proteins that play a key role in innate immunity. They detect and respond to certain molecular patterns of pathogens and other damaging agents.

For more info:


Leave a Reply

Fill in your details below or click an icon to log in: Logo

You are commenting using your account. Log Out /  Change )

Google+ photo

You are commenting using your Google+ account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )


Connecting to %s

%d bloggers like this: