Despite its multitude of benefits, aspirin has recently come under fire again because of an association with age-related macular degeneration (AMD). AMD is a leading cause of vision loss in adults in the developed world. Most severe visual loss is associated with the neovascular (wet) form of AMD, and approximately 200,000 new diagnoses are made each year in the United States.[4,5] Wet AMD is characterized by pathologic angiogenesis with abnormal growth of blood vessels under and into the neurosensory retina. These immature blood vessels can rupture and hemorrhage, a potentially devastating event for the retina in terms of visual function.
Because aspirin use and AMD are both common, a potential association between the 2 has been considered in many studies. Two major approaches have been used to study this association: prospective randomized trials and observational trials.
For more info: http://www.medscape.com/viewarticle/781194