Macugen was the first antiangiogenic therapy to be approved by the FDA. It was shown to be effective in 70% of cases, but did not restore vision in any statistically significant amount.
Lucentis approved since 2008. Shot given every 4 weeks. 95% effective.
Avastin similar to Lucentis but much less expensive
Eyelea approved since 2011. Shot given every 8 weeks.
Photodynamic Therapy (PDT) is a cold laser + dye treatment that is still being used to treat patients with wet AMD, though much less frequently now that useful drugs are available.
Photocoagulation Therapy is a “hot laser” treatment. With the advent of newer therapies, very few “hot” lasers are performed. For years, photocoagulation was the only treatment available for wet AMD.
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