Here are some items from Lauren Tappan worthy of further investigation.
IPAD Herb Halbrecht has already bought one of these marvelous devices. It has large fonts, up to 28 point, and Mac’s Voice-Over text-to-speech.
KINDLE DX This large screen e-book reader is capable of larger font sizes, up to 18 point, and text-to-speech software.
EYE-PAL The Eye-Pal by ABISee Inc scans printed material and instantly converts text to speech or sends the information to a Braille Display for the Blind and Deaf-Blind. Faster than flatbed scanners, the Eye-Pal takes only 3-7 seconds from the keystroke to speech or Braille output.
I-ZOOM i-Zoom is screen magnification / reader software with many of the features of ZoomText. Half the cost of ZoomText but still somewhat expensive. Check out Desktop Zoom as a free alternative. Verify if they work with e-mail and with Word.